Non-invasive prenatal testing (NIPT) test can be requested for any singleton pregnancy, including in vitro fertilization (IVF) pregnancies with egg donors. It can also be requested for twin pregnancies conceived naturally or by IVF using the patient's own egg.

Non-invasive prenatal testing (NIPT) (also known as the Panorama Test, the Harmony Test, or the Verify Test) analyses cell-free DNA circulating in the pregnant mother's blood. It is a new option in prenatal screening for Down syndrome (trisomy 21), and other fetal chromosomal conditions (such as trisomy 18 and 13 or X and Y chromosome problems).

DNA from the fetus circulates in the mother's blood. Cell-free DNA (cfDNA) results from the natural breakdown of fetal cells (presumed to be mostly placental) and clears from the maternal system within hours of giving birth.

During a pregnancy, cfDNA can be tested to give the most accurate screening approach in estimating the risk of a fetus having a common chromosome condition sometimes called a trisomy. This occurs when there are three copies of a particular chromosome instead of the expected two. The test looks to detect Trisomy 21, Trisomy 18 (Edwards syndrome) and Trisomy 13 (Patau syndrome), and Sex chromosome conditions.